June 2002 Bulletin

NIAMS and NIDDK seek research grant applications

By Sandra Lee Breisch

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) are seeking investigator-initiated research grant applications on the role of musculoskeletal microvasculature in fitness and disease. Research that characterizes changes in skeletal muscle perfusion that occur as a result of disease, injury or exercise training is encouraged.

The scope and objectives of this initiative, detailed in Program Announcement (PA-02-104), "Role of Musculoskeletal Microvasculature in Fitness and Disease," encourages applications that clarify two aspects of musculoskeletal microcirculation:

The announcement encourages projects that explore molecular and genomic mechanisms involved in cellular changes in musculoskeletal fluid circulation in response to disease, overuse injuries or changing patterns of physical activity. This includes mechanisms responsible for the detection and signaling of changes in levels of substances such as oxygen and calcium and the mechanisms that mediate adaptive changes in metabolism, oxygen sensing and gene expression. Responses to this program announcement may include studies in appropriate animal models or pre-clinical or clinical studies.

For more information, visit the NIH Web site at http://grants2.nih.gov/grants/guide/pa-files/PA-02-104.html.

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